A general overview of hunter-gatherer archaeology in South America is given by recognizing the main problems in a South American context. Environmental framework and Paleoecological changes are summarized. Pleistocene and Holocene archaeology is reviewed in terms of these particularities. With respect to the Pleistocene, I review Pre-Clovis human presence in South America, technological differences between North and South America, variability in South American subsistence strategy, colonization and demographic models, and migratory routes. The Holocene archaeology is divided into Early and Late. For the former, I consider establishment of adaptive strategies (as marine adaptations), new artifact designs, and mortuary behaviors. For the latter, I consider exchange networks, emergence of complex hunter gatherers, mortuary behavior, origins of food production, and the contact with European populations.