This article provides a brief analytical overview of innovative efforts by the UN to achieve greater coherence in the face of globalization. It is intended to be illustrative, not exhaustive. It examines five instances of this quest and draws some lessons from them: the greater convergence of views about globalization among the main UN actors and other multilateral institutions; the formulation of clear system wide priorities for poverty eradication and related development targets; the endeavor to better coordinate the development assistance that international agencies provide at the country level; some of the UN’s work in information and communication technology intended to help bridge the digital divide; and the Global Compact, engaging global business to advance UN social and environmental principles. But first, some prefatory remarks about the UN system’s architecture are in order.